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    <dc:description xml:lang="ja">SPTLCはスフィンゴ脂質生合成、初発酵素であり細胞の生存に必須である。全身ノックアウトしたホモマウスは胎生初期に死ぬ。本マウスは組織特異的なノックアウトが可能であり、スフィンゴ脂質の研究に有用である。</dc:description>
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    <rdfs:label>B6;129(FVB)-Sptlc2&lt;tm1.1Yhir&gt;</rdfs:label>
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    <ns1:strainDevelopment xml:lang="ja">理研と阪大との共同研究で樹立した。Cre-を選抜し、fl/flの作出を行い、胚保存を実施した。</ns1:strainDevelopment>
    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns5:addinfo>
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    <ns1:strainDevelopment xml:lang="en">Developed by Yoshio Hirabayashi, RIKEN Brain Science Institute in collaboration with Osaka University. R1 ES cell line [(129X1/SvJ x 129S1/Sv)F1] was used. Exon 3 was replaced with a fragment loxP-neo-loxP-Exon3-loxP. Neo fragment was removed by crossing with an EIIa-Cre mouse strain.</ns1:strainDevelopment>
    <dc:description xml:lang="en">Sptlc2(serine palmitoyltransferase, long chain base subunit 2)floxed mice. Homozygous null mutants are embryonically lethal.</dc:description>
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    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Exp. Anim., 58, 515-524 (2009).&lt;br&gt;学術機関の学術研究に限る。営利機関の利用希望者は、事前に利用条件等につき寄託者と合意し、提供承諾を得ること。</ns5:termsAndConditions>
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    <ns1:donorDNA>Phage P1 loxP sites, mouse Sptlc2 genomic DNA</ns1:donorDNA>
    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr09802'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
    <ns5:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Exp. Anim., 58, 515-524 (2009).The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.  For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.</ns5:termsAndConditions>
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    <ns5:addinfo>&lt;A HREF="https://mus.brc.riken.jp/ja/mouse_of_month/jun_2017_mm" target="_blank"&gt;Mouse of the Month Jun 2017&lt;/A&gt;</ns5:addinfo>
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